Expanding the Translational Horizon: 3-Methyladenine as a...
2025-10-18
This thought-leadership article provides a strategic, mechanistic, and translational roadmap for researchers exploring autophagy inhibition, PI3K signaling, and novel cell death pathways in cancer. By leveraging 3-Methyladenine’s unique dual inhibition of class III and class I PI3K, we illuminate new opportunities for experimental innovation, especially at the intersection of autophagy, cuproptosis, and ferroptosis resistance. Drawing on recent advances—including the rational design of copper ionophores to induce cuproptosis—we offer actionable guidance, competitive analysis, and a forward-looking vision for translational oncology.